Kim Min-Wook, Bang Moon-Sug, Han Tae-Ryoon, Ko Young-Jin, Yoon Byung-Woo, Kim Jong-Hyun, Kang La-Mi, Lee Kyoung-Mi, Kim Man-Ho
Department of Rehabilitation Medicine, Our Lady of Mercy Hospital, College of Medicine, The Catholic University of Korea, 655 Bupyong-6-dong, Bypyong-ku, Incheon 403-720, Republic of Korea.
Brain Res. 2005 Aug 2;1052(1):16-21. doi: 10.1016/j.brainres.2005.05.070.
Previous studies have suggested that brain-derived neurotrophic factor (BDNF) and trkB both have a role in plasticity following brain insults and exercise increases BDNF and trkB mRNA levels in the normal brain. We attempted to determine whether treadmill exercise improves motor function following experimental cerebral ischemia, and whether motor outcome is associated with BDNF and trkB expression. We subjected adult male Sprague-Dawley rats to a permanent ischemia, followed by either 12 days of treadmill exercise or non-exercise. In the exercise group, improvements in the motor behavior index were found and BDNF and trkB proteins in contralateral hemisphere were increased. This study suggests that after permanent brain ischemia, exercise improves motor performance and elevates BDNF and trkB proteins in the contralateral hemisphere.
先前的研究表明，脑源性神经营养因子（BDNF）和酪氨酸激酶受体B（trkB）在脑损伤后的可塑性中均发挥作用，并且运动可提高正常大脑中BDNF和trkB的mRNA水平。我们试图确定跑步机运动是否能改善实验性脑缺血后的运动功能，以及运动结果是否与BDNF和trkB的表达相关。我们将成年雄性Sprague-Dawley大鼠进行永久性缺血处理，随后进行12天的跑步机运动或不运动。在运动组中，发现运动行为指数有所改善，且对侧半球的BDNF和trkB蛋白增加。本研究表明，永久性脑缺血后，运动可改善运动表现并提高对侧半球的BDNF和trkB蛋白水平。
