Wong Robert K S, Bianchi Riccardo, Chuang Shih-Chieh, Merlin Lisa R
Department of Physiology and Pharmacology, State University of New York Health Science Center at Brooklyn, USA.
Epilepsy Curr. 2005 Mar-Apr;5(2):63-8. doi: 10.1111/j.1535-7597.2005.05207.x.
The group I metabotropic glutamate receptor subtypes, mGluR1 and mGluR5, have both distinct and overlapping actions in epileptogenesis. Data are reviewed revealing how activation of these receptor subtypes participates in the induction and maintenance of the long-lasting epileptiform discharges elicited in the hippocampal circuit. Differences in the cellular actions and regional distributions of mGluR1 and mGluR5 provide hints regarding the potential usefulness and limitations of subtype-specific antagonists as antiepileptic agents.
I 型代谢型谷氨酸受体亚型 mGluR1 和 mGluR5 在癫痫发生过程中具有不同但又相互重叠的作用。本文综述了相关数据,揭示了这些受体亚型的激活如何参与海马回路中引发的长期癫痫样放电的诱导和维持。mGluR1 和 mGluR5 在细胞作用和区域分布上的差异为亚型特异性拮抗剂作为抗癫痫药物的潜在效用和局限性提供了线索。