回路与兴奋性的调节：对癫痫发生的影响
Regulation of circuits and excitability: implications for epileptogenesis.
作者信息
Hablitz John J
机构信息
Department of Neurobiology, University of Alabama at Birmingham, USA.
出版信息
Epilepsy Curr. 2004 Jul-Aug;4(4):151-3. doi: 10.1111/j.1535-7597.2004.44011.x.
Abstract
Regulation of activity in neuronal circuits is poorly understood. Alterations in regulatory mechanisms may underlie the transition from interictal to ictal activity. Epileptogenesis is thought to arise from hyperexcitability in populations of neurons, resulting from alterations in connectivity and synaptic physiology. Recent studies suggest that excitability in local circuits of neurons also can be changed by short-term plasticity induced by repetitive stimulation and actions of neuromodulators. It is suggested that these factors could be elements underlying excitability changes that contribute to the periodic nature of seizures.
摘要
神经元回路中的活动调节仍未被充分理解。调节机制的改变可能是从发作间期活动向发作期活动转变的基础。癫痫发生被认为源于神经元群体的过度兴奋，这是由连接性和突触生理学的改变所导致的。最近的研究表明，神经元局部回路中的兴奋性也可通过重复刺激和神经调质的作用所诱导的短期可塑性而发生改变。有人提出，这些因素可能是导致兴奋性变化的潜在因素，而兴奋性变化促成了癫痫发作的周期性。
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