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缺血性二尖瓣反流的外科治疗

[Surgical management of ischemic mitral regurgitation].

作者信息

Zheng Si-hong, Meng Xu, Zhang Jian-qun, Gu Cheng-xiong, Bo Ping

机构信息

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2005 Jun 8;85(21):1473-5.

Abstract

OBJECTIVE

To summarize the experience in surgical technique and clinical results of treating ischemic mitral regurgitation (IMR).

METHODS

From April 1998 to September 2004 fifty-three IMR patients, 8 with mild-moderate IMR, 24 with moderate IMR, and 21 with severe IMR, underwent coronary artery bypass grafting (CABG) combined with mitral valvuloplasty (MVP, n = 33) or mitral valve replacement (MVR, n = 20). The procedures of MVP included commissural annuloplasty in 14 cases, posterior ring annuloplasty in 18, and "double-orifice" technique in 1 case. In the cases undergoing MVR, mechanical valves were implanted in 18 patients and biological prosthesis was used in 2. Forty-two patients were followed up by outpatient department visit, telephone, or letter communication for 29 months.

RESULTS

The total operative mortality was 15.09% (8/53) with the causes of death of heart failure in 4 cases, arrhythmia in 2 and multiple organ dysfunction syndrome in 2. Two cases of late death were recorded. Thirty-seven survivors showed the NYHA functional class I-II, and 3 survivors showed the class III. Ultrasonic cardiography showed no or only trace mitral regurgitation (MR) in 17 cases undergoing MVP, mild MR in 6, and moderate MR in 3, all with the left ventricle size decreased significantly. There was 1 case of perivalvular leak in the MVR group. Statistical analysis showed that preoperative left ventricle ejection fraction and cardiac function were independent risk factors of operation, but operation protocol was not.

CONCLUSION

While performing CABG, moderate to severe IMR with pathological changes of mitral valve must be corrected by revascularization and mitral correction. The choice of protocol depends on the mitral pathology and experience of the surgeon. MVP and MVR have the similar effect on IMR.

摘要

目的

总结治疗缺血性二尖瓣反流(IMR)的手术技巧及临床效果。

方法

1998年4月至2004年9月,53例IMR患者接受了冠状动脉旁路移植术(CABG)联合二尖瓣成形术(MVP,n = 33)或二尖瓣置换术(MVR,n = 20),其中轻度至中度IMR 8例,中度IMR 24例,重度IMR 21例。MVP手术方式包括交界环缩术14例,后环环缩术18例,“双孔”技术1例。MVR患者中,18例植入机械瓣膜,2例使用生物瓣膜。42例患者通过门诊复诊、电话或信件随访29个月。

结果

总手术死亡率为15.09%(8/53),死亡原因包括心力衰竭4例,心律失常2例,多器官功能障碍综合征2例。记录到2例晚期死亡。37例幸存者纽约心脏协会(NYHA)心功能分级为Ⅰ-Ⅱ级,3例为Ⅲ级。超声心动图显示,33例接受MVP手术的患者中,17例无或仅有微量二尖瓣反流(MR),6例轻度MR,3例中度MR,左心室大小均显著减小。MVR组有1例瓣周漏。统计分析显示,术前左心室射血分数和心功能是手术的独立危险因素,而手术方式不是。

结论

在进行CABG时,对于伴有二尖瓣病变的中重度IMR,必须通过血运重建和二尖瓣修复来纠正。手术方式的选择取决于二尖瓣病变情况和术者经验。MVP和MVR对IMR的治疗效果相似。

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