癫痫发作后血小板中血清素转运体的减少。
Decrease of serotonin transporters in blood platelets after epileptic seizures.
作者信息
Cupello Aroldo, Favale Emilio, Audenino Daniela, Scarrone Simona, Gastaldi Stefania, Albano Claudio
机构信息
Istituto di Bioimmagini e Fisiologia Molecolare, CNR, Sezione di Genova, Italy.
出版信息
Neurochem Res. 2005 Apr;30(4):425-8. doi: 10.1007/s11064-005-2676-2.
Serotonin transporter (SERT) was studied by [3H]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average KD and BMax were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.
通过[3H] - 帕罗西汀结合法，对对照组和患有全身性惊厥性癫痫的癫痫患者血小板中的5 - 羟色胺转运体（SERT）进行了研究。在这两种情况下，平均解离常数（KD）和最大结合容量（BMax）并无差异。然而，在癫痫发作不到4天的患者血小板膜中，发现5 - 羟色胺转运体密度显著降低。这种情况可能表明对癫痫发作的一种稳态反应。
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