Anno Sumiko, Kudo Susumu, Hamasaki Keita, Matsumura Kazunari, Yamamoto Takushi, Ogata Koretsugu
Department of Engineering, Shibaura Institute of Technology, Tokyo, Japan.
J Physiol Anthropol Appl Human Sci. 2005 Jul;24(4):483-6. doi: 10.2114/jpa.24.483.
We present a conceptual framework for applying techniques of SNP genotyping as a molecular biological approach and remote sensing as an ecological approach to elucidation of the contribution of polygene and environmental factors to inter-individual variation in skin pigmentation phenotype. Additionally, we discuss the obstacles that frustrate our efforts to identify how the human genome encodes the complex phenotype and suggest the use of computational methods designed for knowledge discovery within hereditary database.
我们提出了一个概念框架,将单核苷酸多态性(SNP)基因分型技术作为一种分子生物学方法,将遥感技术作为一种生态学方法,以阐明多基因和环境因素对皮肤色素沉着表型个体间差异的贡献。此外,我们讨论了阻碍我们确定人类基因组如何编码复杂表型的障碍,并建议使用为在遗传数据库中进行知识发现而设计的计算方法。