神经元核抗原（NeuN）在上皮性神经内分泌癌中的表达。
Expression of neuronal nuclear antigen (NeuN) in epithelial neuroendocrine carcinoma.
作者信息
Shuangshoti Shanop, Mujananon Sukrutai, Chaipipat Mookda, Keetacheeva Kanista, Shuangshoti Somruetai
机构信息
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
出版信息
Appl Immunohistochem Mol Morphol. 2005 Sep;13(3):265-7. doi: 10.1097/01.pai.0000137360.34201.21.
Expression of neuronal nuclei (NeuN), a mouse-derived neuronal-specific monoclonal antibody, has been found in almost all neuronal cell types throughout the nervous system. The authors have demonstrated NeuN immunoreactivity in 56% of epithelial neuroendocrine carcinomas (ENEC) (19/34): 4 of 7 (57%) grade 1 ENECs (carcinoid), 4 of 5 (90%) grade 2 ENECs (atypical carcinoid), and 11 of 22 (50%) grade 3 ENECs (small and large cell neuroendocrine carcinoma). Of the NeuN-positive cases, the immunoreactivity was localized primarily in the cytoplasm in 11 cases and in the nucleus in the remaining. Even though NeuN is not a highly sensitive marker for solo use, it would be useful as an adjunct in the panel immunohisto- chemistry of cases with histologic features suspicious of neuroendocrine differentiation.
神经元细胞核（NeuN）是一种源自小鼠的神经元特异性单克隆抗体，在整个神经系统的几乎所有神经元细胞类型中均有发现。作者已在56%（19/34）的上皮性神经内分泌癌（ENEC）中证实了NeuN免疫反应性：7例1级ENEC（类癌）中有4例（57%），5例2级ENEC（非典型类癌）中有4例（90%），22例3级ENEC（小细胞和大细胞神经内分泌癌）中有11例（50%）。在NeuN阳性病例中，免疫反应性主要定位于11例的细胞质中，其余病例定位于细胞核中。尽管NeuN单独使用时不是一个高度敏感的标志物，但在组织学特征怀疑有神经内分泌分化的病例的免疫组化检测中作为辅助指标将很有用。
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