[大鼠坐骨神经修复后缝合部位生物力学特性的动态观察]
[Dynamic observation of the biomechanic properties of sciatic nerve at the suture site in rats following repairing].
作者信息
Yan Jia-zhi, Jiang Bao-guo, Zhao Fu-qiang, Wei Guang-ru, Shang Yong-gang, Zhang Pei-xun, Liu Bo, Zhang Hong-bo
机构信息
Department of Trauma and Orthopedics, People's Hospital of Peking University, Beijing 100044, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2005 Jun 15;43(12):792-4.
OBJECTIVE
To observe the biomechanic properties of sciatic nerve at the suture site in rats following repairing.
METHODS
The right sciatic nerves of 40 white Sprague-Dawley 300-350 gm rats were exposed, cut and then repaired with 10-0 nylon sutures, laced in the epineurium. 0, 1, 3, 6 weeks after operation, the tensile strength of the sciatic nerves were measured, the data analyzed statistically.
RESULTS
The load-elongation curves for both the normal unoperated and operated nerves had the similar shape. The tensile strength of the 0 week was significant difference to 1, 3 and 6 weeks (P < 0.01). No significant difference was found among 1, 3 and 6 weeks.
CONCLUSION
The tensile strength of the injured nerves are recovered in the first week and resistant in 6 weeks after repairing.
目的
观察大鼠坐骨神经修复后缝合部位的生物力学特性。
方法
选取40只体重300 - 350克的白色Sprague-Dawley大鼠，暴露其右侧坐骨神经，切断后用10-0尼龙缝线在神经外膜进行缝合。术后0、1、3、6周，测量坐骨神经的拉伸强度，并对数据进行统计学分析。
结果
正常未手术神经和手术神经的载荷-伸长曲线形状相似。0周时的拉伸强度与1、3、6周时差异有统计学意义（P < 0.01）。1、3、6周之间未发现显著差异。
结论
损伤神经的拉伸强度在修复后第1周开始恢复，6周后趋于稳定。
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