Warner Brad W, Warner Barbara B
Division of Pediatric and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
Semin Pediatr Surg. 2005 Aug;14(3):175-80. doi: 10.1053/j.sempedsurg.2005.05.006.
Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed.
新生儿坏死性小肠结肠炎（NEC）是早产儿中越来越常见的一种病症，其病因尚不完全清楚。表皮生长因子（EGF）在许多与胎儿和新生儿胃肠道接触的液体中含量丰富，包括羊水、唾液和母乳。EGF被认为对正常肠道发育以及胃肠道黏膜损伤后的修复很重要。似乎有越来越多的证据支持EGF产生不足与NEC的发生之间可能存在联系。本文将综述EGF在肠道发育和黏膜修复中的作用的相关证据，以及其在NEC发病机制中的潜在作用。
