Nir Tomer, Dor Yuval
Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Curr Opin Biotechnol. 2005 Oct;16(5):524-9. doi: 10.1016/j.copbio.2005.07.005.
One promising approach for the cure of diabetes is the replacement of lost insulin-expressing beta cells by cell or regenerative therapy. The recent development of an effective islet transplantation procedure has focused attention on the limiting supply of beta cells. Various sources for new beta cells are therefore being considered, including embryonic stem cells, adult stem cells and transdifferentiation of certain types of differentiated cells, so far with limited success. The major physiological mechanism for adult beta cell formation was recently shown to be beta cell proliferation. This finding underscores the potential use of terminally differentiated beta cells as a starting material for enhancement of beta cell mass.
治疗糖尿病的一种有前景的方法是通过细胞或再生疗法替代缺失的表达胰岛素的β细胞。有效胰岛移植程序的最新进展使人们将注意力集中在β细胞供应受限的问题上。因此，正在考虑多种新β细胞来源，包括胚胎干细胞、成体干细胞以及某些类型分化细胞的转分化，但目前成效有限。最近研究表明，成体β细胞形成的主要生理机制是β细胞增殖。这一发现突出了终末分化的β细胞作为增加β细胞数量起始材料的潜在用途。
