既往口服避孕药与绝经后骨折：一项女性健康倡议观察性队列研究。

Prior oral contraception and postmenopausal fracture: a Women's Health Initiative observational cohort study.

作者信息

Barad David, Kooperberg Charles, Wactawski-Wende Jean, Liu James, Hendrix Susan L, Watts Nelson B

机构信息

Obstetrics and Gynecology & Women's Health, Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York 10021, USA.

出版信息

Fertil Steril. 2005 Aug;84(2):374-83. doi: 10.1016/j.fertnstert.2005.01.132.

DOI:10.1016/j.fertnstert.2005.01.132

PMID:16084878

Abstract

OBJECTIVE

To test for the possible association of past oral contraceptive (OC) use and incident fracture after menopause.

DESIGN

A prospective cohort of 93,725 postmenopausal women.

SETTING

Forty Women's Health Initiative (WHI) clinical centers across the United States.

PATIENT(S): Ethnically diverse 93,725 volunteer postmenopausal women, 50 to 79 years old.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): The main outcome was self-reported incident first fracture assessed prospectively by annual questionnaire.

RESULT(S): The adjusted relative hazard (HR) for fracture among past OC users was 1.07 (95% CI, 1.01-1.15). Among women without any postmenopausal hormone treatment, past OC use for < or =5 years led to an HR of 1.15 (95% CI, 1.04-1.27) and for past OC use >5 years led to an HR of 1.09 (95% CI, 0.97-1.23) compared with never users.

CONCLUSION(S): This study does not support the idea that past OC use protects against later fracture.

摘要

目的

检测既往口服避孕药（OC）使用与绝经后骨折发生之间可能存在的关联。

设计

对93725名绝经后女性进行前瞻性队列研究。

地点

美国40个妇女健康倡议（WHI）临床中心。

患者

93725名50至79岁的不同种族绝经后志愿女性。

干预措施

无。

主要观察指标

主要观察指标是通过年度问卷前瞻性评估的自我报告的首次骨折事件。

结果

既往口服避孕药使用者骨折的校正相对风险（HR）为1.07（95%可信区间，1.01 - 1.15）。在未接受任何绝经后激素治疗的女性中，与从未使用者相比，既往口服避孕药使用≤5年导致HR为1.15（95%可信区间，1.04 - 1.27），既往口服避孕药使用>5年导致HR为1.09（95%可信区间，0.97 - 1.23）。