对于乳腺T1期浸润性纯管状癌，是否有必要进行腋窝淋巴结清扫术？

Is complete axillary lymph node dissection neccessary in T1 stage invasive pure tubular carcinomas of the breast?

作者信息

Fernández-Aguilar Sergio, Simon Philippe, Buxant Frédéric, Fayt Isabelle, Nöel Jean-Christophe

机构信息

Department of Pathology, Erasmus University Hospital, 808 Route de Lennik, 1070 Brussels, Belgium.

出版信息

Breast. 2005 Aug;14(4):325-8. doi: 10.1016/j.breast.2004.12.002.

DOI:10.1016/j.breast.2004.12.002

PMID:16085240

Abstract

The purpose of this study was to evaluate the frequency of axillary lymph node metastasis in invasive pure (not mixed) tubular carcinomas of the breast and to compare our results to other series published in the literature. We analyzed 16 cases of pure tubular carcinoma measuring 2 cm or less in diameter from our database from 1988 to 2004 diagnosed in lumpectomy and mastectomy specimens with associated axillary lymph node dissection. Histopathologic features were reviewed in all patients. In all cases, no axillary lymph node metastasis was observed (0%). These data slightly differ from the results of some studies recently published in the literature, in which the overall nodal involvement in pure tubular carcinomas ranges from 0% to 20%. We conclude that in invasive pure tubular carcinomas of the breast measuring less than 2 cm in diameter, complete axillary lymph node dissection should be avoided, and we propose a sentinel lymph node analysis instead.

摘要

本研究的目的是评估乳腺浸润性纯（非混合性）管状癌腋窝淋巴结转移的频率，并将我们的结果与文献中发表的其他系列研究进行比较。我们分析了1988年至2004年从我们数据库中选取的16例直径2 cm或更小的纯管状癌病例，这些病例均在接受肿块切除术和乳房切除术标本时进行了相关腋窝淋巴结清扫。对所有患者的组织病理学特征进行了复查。所有病例均未观察到腋窝淋巴结转移（0%）。这些数据与最近文献中发表的一些研究结果略有不同，在那些研究中，纯管状癌的总体淋巴结受累率为0%至20%。我们得出结论，对于直径小于2 cm的乳腺浸润性纯管状癌，应避免进行完整的腋窝淋巴结清扫，我们建议采用前哨淋巴结分析。