Berry James D, Petersen Karin Lottrup
UCSF Pain Clinical Research Center, Department of Neurology, University of California, San Francisco, CA, USA.
Neurology. 2005 Aug 9;65(3):444-7. doi: 10.1212/01.wnl.0000168259.94991.8a.
This randomized, double-blind, placebo-controlled crossover study measured the effect of a single dose of oral gabapentin (900 mg) on pain and allodynia associated with herpes zoster. Pain severity decreased by 66% with gabapentin compared to 33% with placebo. Reductions in allodynia area and severity, and overall pain relief, were also greater with gabapentin.
这项随机、双盲、安慰剂对照的交叉研究测量了单剂量口服加巴喷丁(900毫克)对带状疱疹相关疼痛和痛觉过敏的影响。与安慰剂组33%的疼痛缓解率相比,加巴喷丁组的疼痛严重程度降低了66%。加巴喷丁在减轻痛觉过敏面积和严重程度以及总体疼痛缓解方面也更有效。