Wroblewska M, Swoboda-Kopec E, Kawecki D, Sawicka-Grzelak A, Stelmach E, Luczak M
Dept. of Medical Microbiology, Medical University of Warsaw, 5 Chalubinskiego Street, 02-004 Warsaw, Poland.
Infection. 2005 Aug;33(4):289-91. doi: 10.1007/s15010-005-4123-3.
Infections caused by dimorphic fungi, rarely observed in a temperate climate, may cause chronic infections in immunocompromised patients. We describe a case of sporotrichosis in a 50-year-old woman, who underwent mastectomy due to breast carcinoma, followed by radiation and chemotherapy. She developed skin lesions, localized along the lymphatics. Discharge samples repeatedly yielded a characteristic growth of the dimorphic fungus Sporothrix schenckii. The isolate was resistant to all commonly used antifungal agents, except for itraconazole. Therapy with this antifungal agent resulted in disappearance of the clinical symptoms.
双相真菌引起的感染在温带气候中很少见，可能在免疫功能低下的患者中引起慢性感染。我们描述了一例50岁女性的孢子丝菌病病例，该患者因乳腺癌接受了乳房切除术，随后进行了放疗和化疗。她出现了沿淋巴管分布的皮肤病变。分泌物样本多次培养出双相真菌申克孢子丝菌的特征性生长。该分离株对所有常用抗真菌药物耐药，伊曲康唑除外。使用这种抗真菌药物治疗后临床症状消失。
