Jülg B, Goebel F D
Dept. of Infectious Diseases, Medical Policlinic, Ludwig Maximilian University Munich, Pettenkoferstr. 8a, 80336 Munich, Germany.
Infection. 2005 Aug;33(4):299-301. doi: 10.1007/s15010-005-6405-1.
At least nine different genetic HIV-1 subtypes and several circulating recombinant forms exist, which in addition to HIV-1 subgroups and HIV-2 account for the global AIDS pandemic. Even though HIV-1 subtype C and A predominate globally, antiretroviral drugs have been designed based on sequences of clade B reverse transcriptase (RT) and protease enzymes due to the domination of HIV-1 subtype B in highly industrialized countries. Since there is no clarity about possible effects of the genetic diversity of HIV-1 on therapy outcome and drug resistance, multiple studies have been performed with divergent results. Up to now this question remains to be answered.
至少存在九种不同的基因HIV-1亚型和几种流行的重组形式，除HIV-1亚组和HIV-2外，这些共同构成了全球艾滋病大流行。尽管HIV-1 C亚型和A亚型在全球占主导地位，但由于HIV-1 B亚型在高度工业化国家占主导地位，抗逆转录病毒药物是根据B亚型逆转录酶（RT）和蛋白酶的序列设计的。由于目前尚不清楚HIV-1基因多样性对治疗结果和耐药性可能产生的影响，因此已经进行了多项研究，但结果不一。到目前为止，这个问题仍有待解答。
