Baynard Tracy, Franklin Ruth M, Goulopoulou Styliani, Carhart Robert, Kanaley Jill A
Department of Exercise Science, Syracuse University, Syracuse, NY 13244, USA.
Metabolism. 2005 Aug;54(8):989-94. doi: 10.1016/j.metabol.2005.02.015.
The Surgeon General and Centers for Disease Control and Prevention have recommended that multiple bouts of exercise can be accumulated throughout the day in lieu of the more traditional single, longer bout of exercise. Yet, conclusive evidence does not exist suggesting these 2 training modes provide similar health-related benefits on metabolic control, especially in individuals with type 2 diabetes. The purpose of this study was to determine if differences exist in glucose control when preceded by one 30-minute or three 10-minute bouts of exercise in women with type 2 diabetes. Nine individuals with type 2 diabetes (53 +/- 6 years old) and 6 control women (49 +/- 4 years old) completed 3 randomly ordered oral glucose tolerance tests (OGTTs). Two of the OGTTs were preceded the day prior by moderate exercise (approximately 60% of Vo2peak), either one 30-minute or three 10-minute bouts, whereas the third OGTT was used as a control day with no exercise performed 3 days prior. Glucose and insulin were measured every 30 minutes for 4 hours during the OGTT. Individuals with type 2 diabetes exhibited a greater overall glucose response than the controls (P < .05), but the glucose response to the OGTT was not different between the 3 conditions within each group (2-hour glucose: multiple bout, 14.3 +/- 3.2 vs 5.0 +/- 1.7; single bout, 14.1 +/- 3.0 vs 4.7 +/- 1.5; control day, 14.6 +/- 2.7 vs 4.9 +/- 4.9 mmol/L). Glucose area under the curve analysis resulted in similar findings. As expected, the group with type 2 diabetes had greater fasting insulin levels compared with the control group for all exercise conditions (multiple bout: 4.5 +/- 1.2 vs 0.3 +/- 0.2; single bout: 6.4 +/- 1.6 vs 0.9 +/- 0.4; control day: 5.7 +/- 1.8 vs 1.5 +/- 0.6 pmol/L; P < .05). Exercise or no exercise did not alter the insulin response to the OGTT for either group. Despite a higher glucose response to the glucose load in T2D, an acute exercise bout (single or multiple bouts) did not appear to alter glucose control the following day in either the individuals with type 2 diabetes or the control group.
美国卫生局局长及疾病控制与预防中心建议，可在一天中累积进行多次锻炼，以替代更为传统的单次较长时间锻炼。然而，尚无确凿证据表明这两种训练模式在代谢控制方面能带来相似的健康益处，尤其是在2型糖尿病患者中。本研究的目的是确定2型糖尿病女性在进行一次30分钟或三次10分钟的锻炼后，血糖控制是否存在差异。9名2型糖尿病患者（53±6岁）和6名对照女性（49±4岁）完成了3次随机排序的口服葡萄糖耐量试验（OGTT）。其中两次OGTT在试验前一天进行了中等强度运动（约为最大摄氧量的60%），一次为30分钟，另一次为三次10分钟，而第三次OGTT作为对照日，试验前3天未进行运动。在OGTT期间，每30分钟测量一次血糖和胰岛素，持续4小时。2型糖尿病患者的总体血糖反应高于对照组（P<0.05），但每组内三种条件下对OGTT的血糖反应无差异（2小时血糖：多次锻炼组，14.3±3.2 vs 5.0±1.7；单次锻炼组，14.1±3.0 vs 4.7±1.5；对照日，14.6±2.7 vs 4.9±4.9 mmol/L）。曲线下面积分析得出了类似的结果。正如预期的那样，在所有运动条件下，2型糖尿病组的空腹胰岛素水平均高于对照组（多次锻炼组：4.5±1.2 vs 0.3±0.2；单次锻炼组：6.4±1.6 vs 0.9±0.4；对照日：5.7±1.8 vs 1.5±0.6 pmol/L；P<0.05）。锻炼与否均未改变两组对OGTT的胰岛素反应。尽管2型糖尿病患者对葡萄糖负荷的血糖反应较高，但无论是2型糖尿病患者还是对照组，急性锻炼（单次或多次）次日似乎都未改变血糖控制情况。
