Szumiło Justyna, Swatek Jarosław, Chrościcki Andrzej, Dudka Jarosław, Korobowicz Elzbieta
Department of Clinical Pathomorphology, Prof. Feliks Skubiszewski Medical University of Lublin.
Pol J Pathol. 2005;56(2):89-92.
Numerous granular eosinophilic cells corresponding to Paneth cells were unexpectedly revealed in a moderately differentiated adenocarcinoma of the hepatic flexure of the colon in a 76-year-old man. These cells were clearly seen in routine slides and their nature was confirmed by Masson's trichrome stain, by immunohistochemical reaction for lysozyme, and by electron microscopy. The tumor contained also cells intermediate between Paneth and goblet cells (with both supranuclear granules and mucous globules), observed in Masson's trichrome stain and in electron microscope. Additionally, immunohistochemical reaction for chromogranin A was performed and irregularly scattered neoplastic endocrine cells were visualized in the tumor. The light microscopic and ultrastructural features of this rare neoplasm are described together with detailed clinical data. The incidence and significance of the Paneth cell and endocrine differentiation in colorectal carcinomas are discussed with the review of the literature.
在一名76岁男性结肠肝曲中分化腺癌中，意外发现了大量对应潘氏细胞的颗粒状嗜酸性细胞。这些细胞在常规切片中清晰可见，其性质通过马松三色染色、溶菌酶免疫组化反应及电子显微镜得以证实。肿瘤中还含有介于潘氏细胞和杯状细胞之间的细胞（具有核上颗粒和黏液球），在马松三色染色及电子显微镜下均可观察到。此外，还进行了嗜铬粒蛋白A免疫组化反应，在肿瘤中可见不规则散在的肿瘤内分泌细胞。本文描述了这种罕见肿瘤的光镜和超微结构特征以及详细的临床资料。结合文献复习，讨论了结直肠癌中潘氏细胞和内分泌分化的发生率及意义。
