Reznicek M J, Cordle D G, Strauss R G
DeGowin Blood Center, University of Iowa Hospitals and Clinics, Iowa City 52242.
Vox Sang. 1992;62(3):173-5. doi: 10.1111/j.1423-0410.1992.tb01193.x.
Anti-Sda, an antibody not usually considered to cause of hemolytic transfusion reactions, possibly was related to hemolysis following transfusion of red blood cells expressing strong Sda antigen. Prior to transfusion, the antiglobulin antibody screen performed in LISS and an immediate spin crossmatch were negative. Retrospectively, after hemolysis was detected, an antiglobulin crossmatch with red cells from the transfused unit revealed microscopic incompatibility. The transfused unit proved to have strong expression of Sda antigen-facilitating identification of a weak Sda antibody in our patient. In addition, this case represents an unusual instance in which an antibody screen plus an immediate spin crossmatch failed to detect an incompatibility that would have been apparent had an antiglobulin crossmatch been performed.
抗Sda抗体通常不被认为是引起溶血性输血反应的原因，但可能与输注表达强Sda抗原的红细胞后的溶血有关。输血前，在低离子强度盐溶液（LISS）中进行的抗球蛋白抗体筛查和立即离心交叉配血均为阴性。回顾性分析，在检测到溶血后，与输注单位的红细胞进行的抗球蛋白交叉配血显示出微观不相容性。输注单位被证明具有强Sda抗原表达，这有助于识别我们患者体内的弱Sda抗体。此外，该病例代表了一种不寻常的情况，即抗体筛查加立即离心交叉配血未能检测到不相容性，而如果进行抗球蛋白交叉配血则会明显发现这种不相容性。
