Duff S E, Saunders M, McCredie V, Kumar S, O'Dwyer S T, Jayson G C
Department of Surgery, Christie Hospital NHS Trust, Manchester, UK.
Clin Oncol (R Coll Radiol). 2005 Aug;17(5):367-71. doi: 10.1016/j.clon.2005.03.002.
Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis.
One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays.
No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml [range, 4.9-51.9] vs 9.9 U/ml [4.4-93.4 U/ml]; P = 0.90; VEGF-D: 335 pg/ml [113-1102] vs 316.5 pg/ml [0-1343]; P = 0.68).
Circulating plasma levels of VEGF-C and VEGF-D do not allow pre-operative identification of lymph-node status in patients with colorectal cancer.
血管内皮生长因子（VEGF）-C和VEGF-D是VEGF生长因子家族中具有血管生成和淋巴管生成作用的成员。人类肿瘤中VEGF-C或VEGF-D表达增加可能与淋巴结转移和淋巴管浸润有关。本研究检测了结直肠癌患者循环血浆中VEGF-A、VEGF-C和VEGF-D的水平，并评估其作为判断淋巴结转移诊断工具的效用。
本研究纳入了120例结直肠癌患者和50例健康对照者。采用酶联免疫吸附测定法评估血浆生长因子水平。
根据临床病理变量分组的患者之间，血浆VEGF-C或VEGF-D水平无显著差异。特别是，有或无淋巴结受累的患者血浆VEGF-C或VEGF-D水平中位数无差异（VEGF-C：11.2 U/ml[范围，4.9 - 51.9] vs 9.9 U/ml[4.4 - 93.4 U/ml]；P = 0.90；VEGF-D：335 pg/ml[113 - 1102] vs 316.5 pg/ml[0 - 1343]；P = 0.68）。
循环血浆中VEGF-C和VEGF-D水平无法在术前识别结直肠癌患者的淋巴结状态。
