甲磺酸培氟沙星与三种环糊精包合物的制备与表征
Preparation and characterization of inclusion complexes of pefloxacin mesylate with three kinds of cyclodextrins.
作者信息
Chao Jian-Bin, Tong Hong-Bo, Liu Dian-Sheng, Huang Shu-Ping
机构信息
Institute of Modern Chemistry, Shanxi University, Taiyuan 030006, China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2006 May 1;64(1):166-70. doi: 10.1016/j.saa.2005.07.012. Epub 2005 Aug 10.
The ability of alpha-cyclodextrin, beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin (alpha-CD, beta-CD and HP-beta-CD) to break pefloxacin mesylate (PM) aggregates by forming inclusion complexes has been studied using 1H NMR (nuclear magnetic resonance spectroscopy), 13C NMR and fluorescence spectra. The inclusion constants are determined to compare the corresponding inclusion capacity. Solid-inclusion complexes of PM with CDs are synthesized by coprecipitation method, and all the inclusion ratios are found to be 1:1. Additionally, spatial characterization of complexes has been proposed based on two-dimensional nuclear magnetic resonance technique (2D NMR) and spatial conformation is also investigated to propose two possible models between PM and CDs.
利用1H核磁共振（核磁共振光谱法）、13C核磁共振和荧光光谱研究了α-环糊精、β-环糊精和羟丙基-β-环糊精（α-CD、β-CD和HP-β-CD）通过形成包合物来破坏甲磺酸培氟沙星（PM）聚集体的能力。测定了包合常数以比较相应的包合能力。通过共沉淀法合成了PM与环糊精的固体包合物，发现所有包合比均为1:1。此外，基于二维核磁共振技术（2D NMR）对配合物进行了空间表征，并研究了空间构象，提出了PM与环糊精之间的两种可能模型。
Zotero 插件