Levisetti Matteo G, Polonsky Kenneth S
Department of Medicine Washington University School of Medicine St.Louis, Missouri 63110, USA.
Cell Metab. 2005 Aug;2(2):78-80. doi: 10.1016/j.cmet.2005.07.005.
A complex network of interacting transcription factors plays a critical role in normal pancreatic beta cell function, with mutations in certain transcription factor genes known to cause diabetes. In a recent issue of Cell, Gunton et al.(2005) demonstrate a role for the transcription factor ARNT/HIF1beta (hydrocarbon nuclear receptor translocator/hypoxia-inducible factor 1 beta) in normal beta cell function. ARNT expression is reduced in diabetic human islets and beta cell-specific ARNT knockout mice show the impaired glucose tolerance and abnormal insulin secretion that are characteristic of type 2 diabetes.
一个由相互作用的转录因子构成的复杂网络在正常胰腺β细胞功能中起着关键作用，已知某些转录因子基因的突变会导致糖尿病。在最近一期的《细胞》杂志上，冈顿等人（2005年）证明了转录因子ARNT/HIF1β（烃核受体转运体/缺氧诱导因子1β）在正常β细胞功能中的作用。在糖尿病患者的胰岛中，ARNT的表达降低，并且β细胞特异性ARNT基因敲除小鼠表现出2型糖尿病特有的糖耐量受损和胰岛素分泌异常。
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