Systematic strategies for improved outcomes for the hyperglycemic hospitalized patient with diabetes mellitus.

Diabetes mellitus is reaching epidemic proportions in the United States. It is now the fourth most common comorbid condition complicating hospital discharges. There is a rapidly evolving body of literature assessing the short-term and long-term effects of strict glycemic control in the hospital setting. Results from several landmark studies have challenged the long-held notion that stress hyperglycemia is beneficial. This article will focus on these studies, postulated mechanisms of action, and finally, description of an insulin infusion protocol developed at a community hospital for patients undergoing cardiac surgery.