普瑞巴林的杂芳族侧链类似物。
Heteroaromatic side-chain analogs of pregabalin.
作者信息
Schelkun Robert M, Yuen Po-wai, Wustrow David J, Kinsora Jack, Su Ti-Zhi, Vartanian Mark G
机构信息
PGRD Michigan Laboratories, Ann Arbor, MI 48105, USA.
出版信息
Bioorg Med Chem Lett. 2006 May 1;16(9):2329-32. doi: 10.1016/j.bmcl.2005.06.090. Epub 2005 Aug 15.
PMID:16099652
Abstract
A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
摘要
已鉴定出一系列普瑞巴林的杂芳族类似物，它们在DBA/2小鼠模型中具有抗惊厥活性。本文讨论了其合成方法和初步药理学。
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