Production of the radioactive antitumoral cisplatin.

作者信息

Leal Alexandre S, Carvalho Júnior Alvaro D, Abrantes Fabiana M, Menezes Maria Angela de B C, Ferraz Vany, Cruz Tamara S, Cardoso Valbert N, de Oliveira Mônica C

机构信息

Division for Radiation Technology, Nuclear Technology Development Centre (CDTN)/National Commission for Nuclear Energy (CNEN), P.O. Box 941, CEP 30123-970, Belo Horizonte, Minas Gerais, Brazil.

出版信息

Appl Radiat Isot. 2006 Feb;64(2):178-81. doi: 10.1016/j.apradiso.2005.07.004. Epub 2005 Aug 15.

DOI:10.1016/j.apradiso.2005.07.004

PMID:16099666

Abstract

This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.

摘要