[乙二胺四乙酸依赖性假性血小板减少症：临床特征与实验室检查]

[EDTA-dependent pseudothrombocytopenia: clinical aspects and laboratory tests].

作者信息

Saigo Katsuyasu, Sakota Yasuyuki, Masuda Yukako

机构信息

Blood Transfusion Division, Kobe University Hospital, Kobe 650-0017.

出版信息

Rinsho Byori. 2005 Jul;53(7):646-53.

PMID:16104534

Abstract

EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is a phenomenon caused by EDTA-dependent anti-platelet antibody. This antibody induces platelet agglutination in vitro, resulting in a decrease in platelet counts. It is necessary for clinicians to consider the possible presence of PTCP in cases of patients having low platelet counts without any hemorrhagic tendency. In this article, we describe some aspects of EDTA-PTCP including, (1) characteristics of platelet agglutination, (2)possible mechanisms for antibody production, (3) several methods to determine the true platelet number, and also (4) a few similar phenomena induced by antibodies independent of EDTA.

摘要

乙二胺四乙酸（EDTA）依赖性假性血小板减少症（EDTA-PTCP）是一种由EDTA依赖性抗血小板抗体引起的现象。这种抗体在体外诱导血小板凝集，导致血小板计数减少。对于血小板计数低且无任何出血倾向的患者，临床医生有必要考虑可能存在PTCP。在本文中，我们描述了EDTA-PTCP的一些方面，包括：（1）血小板凝集的特征；（2）抗体产生的可能机制；（3）几种确定真实血小板数量的方法；以及（4）一些由非EDTA依赖性抗体诱导的类似现象。