Risk factors and outcomes of pancreatitis after open heart surgery.

作者信息

Perez Alexander, Ito Hiromichi, Farivar Robert S, Cohn Lawrence H, Byrne John G, Rawn James D, Aranki Sary F, Zinner Michael J, Tilney Nicholas L, Brooks David C, Ashley Stanley W, Banks Peter A, Whang Edward E

机构信息

Department of Surgery, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Am J Surg. 2005 Sep;190(3):401-5. doi: 10.1016/j.amjsurg.2005.03.004.

DOI:10.1016/j.amjsurg.2005.03.004

PMID:16105526

Abstract

BACKGROUND

We sought to analyze the risk factors and natural history associated with post-cardiac surgery acute pancreatitis.

METHODS

Retrospective analysis of all patients having undergone cardiac surgery at our hospital between January 1, 1992, and October 1, 2001.

RESULTS

A total of 10,249 cardiac operations were performed. Thirty-nine (0.4%) patients developed postoperative pancreatitis. There was a higher incidence during the period spanning 1992 through 1996 than 1997 through 2001 (0.6% versus 0.2%, P< .05). Patients with pancreatitis had longer postoperative length of stay (51+/-5 days versus 10+/-1 days, P<.05) and a greater in-hospital mortality rate (28% versus 4%, P<.05) than patients who did not develop pancreatitis. A history of alcohol abuse, cardiac surgery performed during 1992 to 1996, increased cardiopulmonary bypass time, and increased cross-clamp time were independent risk factors for the development of pancreatitis. Multiple-organ failure was an independent predictor for death among patients with pancreatitis.