Shao Zhi-qiang, Zheng Shao-bin, Xiao Yao-jun, Tan Wan-long, Chen Tong, Qi Huan, Jiang Yao-dong, Yu Zhao-cun, Zhang Hui-Jian
Department of Urology, Southern Hospital, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Aug;25(8):1034-6.
To explore the expression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in renal cell carcinoma (RCC) and their relationship.
The expression of HIF-1alphaand VEGF was examined in 42 patients with renal cell carcinoma by SABC methods of immunohistochemistry.
The positivity rate of HIF-1alpha was 57.1% in the RCC tissues, and there was no expression in the tissue adjacent to the tumor and normal tissues. The positivity rate of VEGF was 61.9% in the tumor tissues, with significant difference from the control tissues (P<0.05). The expression levels of HIF-1alpha and VEGF were significantly higher in metastatic RCC than in non-metastatic RCC (P<0.01) tissues, and there was a significant correlation between HIF-1alpha and VEGF expressions (Kappa=0.41, P<0.01).
HIF-1alpha is highly expressed in renal cell carcinoma tissues in close correlation with VEGF. HIF-1alpha and VEGF may serve as important indicators to evaluate the biological behaviors of RCC such as metastasis and prognosis. HIF-1alpha is an important regulator of VEGF.
探讨缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）在肾细胞癌（RCC）中的表达及其关系。
采用免疫组织化学SABC法检测42例肾细胞癌患者中HIF-1α和VEGF的表达。
肾细胞癌组织中HIF-1α阳性率为57.1%，癌旁组织及正常组织均无表达。肿瘤组织中VEGF阳性率为61.9%，与对照组织相比差异有统计学意义（P<0.05）。转移性肾细胞癌组织中HIF-1α和VEGF的表达水平显著高于非转移性肾细胞癌组织（P<0.01），且HIF-1α与VEGF表达之间存在显著相关性（Kappa=0.41，P<0.01）。
HIF-1α在肾细胞癌组织中高表达，与VEGF密切相关。HIF-1α和VEGF可能作为评估肾细胞癌转移和预后等生物学行为的重要指标。HIF-1α是VEGF的重要调节因子。
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