G2D：一种挖掘与疾病相关基因的工具。
G2D: a tool for mining genes associated with disease.
作者信息
Perez-Iratxeta Carolina, Wjst Matthias, Bork Peer, Andrade Miguel A
机构信息
Ontario Genomics Innovation Centre, Ottawa Health Research Institute, ON K1H 8L6, Ottawa, Canada.
出版信息
BMC Genet. 2005 Aug 22;6:45. doi: 10.1186/1471-2156-6-45.
BACKGROUND
Human inherited diseases can be associated by genetic linkage with one or more genomic regions. The availability of the complete sequence of the human genome allows examining those locations for an associated gene. We previously developed an algorithm to prioritize genes on a chromosomal region according to their possible relation to an inherited disease using a combination of data mining on biomedical databases and gene sequence analysis.
RESULTS
We have implemented this method as a web application in our site G2D (Genes to Diseases). It allows users to inspect any region of the human genome to find candidate genes related to a genetic disease of their interest. In addition, the G2D server includes pre-computed analyses of candidate genes for 552 linked monogenic diseases without an associated gene, and the analysis of 18 asthma loci.
CONCLUSION
G2D can be publicly accessed at http://www.ogic.ca/projects/g2d_2/.
背景
人类遗传性疾病可通过基因连锁与一个或多个基因组区域相关联。人类基因组完整序列的可得性使得能够检查这些区域以寻找相关基因。我们之前开发了一种算法，通过结合生物医学数据库的数据挖掘和基因序列分析，根据基因与遗传性疾病的可能关系对染色体区域上的基因进行优先级排序。
结果
我们已将此方法作为一个网络应用程序在我们的G2D（基因与疾病）网站上实现。它允许用户检查人类基因组的任何区域，以找到与其感兴趣的遗传疾病相关的候选基因。此外，G2D服务器包括对552种无相关基因的连锁单基因疾病的候选基因的预先计算分析，以及对18个哮喘位点的分析。
结论
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