长期暴露于吗啡会导致猫的外侧膝状体（LGN）细胞感受野特性的退化。
Chronic morphine exposure induces degradation of receptive field properties of LGN cells in cats.
作者信息
He Li-hua, Li Guang-xing, Li Xiang-rui, Zhou Yi-feng
机构信息
Hefei National Laboratory for Physical Sciences at Microscale and School of Life Science, University of Science and Technology of China, Hefei 230027, China.
出版信息
Acta Pharmacol Sin. 2005 Sep;26(9):1034-8. doi: 10.1111/j.1745-7254.2005.00190.x.
AIM
To investigate the effect of chronic morphine exposure on the receptive field properties of lateral geniculate nucleus (LGN) neurons in cats.
METHODS
Cats were injected with morphine (10 mg/kg) or saline twice daily, for 10 d. Subsequently, extracellular single-unit recording techniques were used to examine the sensitivity of LGN neurons to visual stimuli in chronic morphine-treated and saline-treated cats.
RESULTS
Compared with saline-treated cats (as controls), LGN neurons in morphine-treated cats had decreased signal-to-noise ratios (1.9 vs 3.1), and orientation and direction sensitivity (0.103 vs 0.135 and 0.074 vs 0.10, respectively), accompanied by significant increases in spontaneous (27.4 vs 17.5) and evoked activity (preferred: 42.2 vs 38.1; average: 28.1 vs 22.3).
CONCLUSION
Chronic morphine exposure can lead to the functional degradation of LGN neurons in cats, which might result from the effects of chronic morphine exposure on inhibitory neurotransmission.
目的
研究慢性吗啡暴露对猫外侧膝状体（LGN）神经元感受野特性的影响。
方法
猫每天注射两次吗啡（10毫克/千克）或生理盐水，持续10天。随后，采用细胞外单单位记录技术检测慢性吗啡处理组和生理盐水处理组猫的LGN神经元对视觉刺激的敏感性。
结果
与生理盐水处理组猫（作为对照）相比，吗啡处理组猫的LGN神经元信噪比降低（分别为1.9对3.1），方向和方向敏感性降低（分别为0.103对0.135和0.074对0.10），同时自发放电（27.4对17.5）和诱发活动显著增加（偏好：42.2对38.1；平均：28.1对22.3）。
结论
慢性吗啡暴露可导致猫LGN神经元功能退化，这可能是慢性吗啡暴露对抑制性神经传递产生影响的结果。
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