Park K G, Heys S D, Murray J B, Hayes P D, Ashby J A, Franks C R, Eremin O
Department of Surgery, Aberdeen University, Foresterhill, UK.
Cancer Immunol Immunother. 1992;35(1):53-8. doi: 10.1007/BF01741055.
Natural cytotoxicity (natural killer, NK, and lymphokine-activated killer, LAK, activity) was documented in 12 patients with metastatic colorectal cancer, both before and after a 5-day course of continuous therapy with intravenous recombinant interleukin-2 (rIL-2). Treatment induced a substantial increase in circulating CD56+ lymphocytes (pretreatment: 12.1 +/- 6.9%, mean +/- SD; posttreatment: 39.2 +/- 6.9%. Maximal NK cell activity was induced by treatment with rIL-2 but only suboptimal augmentation of LAK cell cytotoxicity was obtained. This study indicates that although continuous infusion of rIL-2 does have a significant effect on natural cytotoxicity, this is suboptimal and further studies are necessary to define the most efficacious immunity-enhancing regimens of therapy, thereby hopefully improving clinical outcome of rIL-2 treatment.
在12例转移性结直肠癌患者中,记录了其在静脉注射重组白细胞介素-2(rIL-2)进行为期5天的连续治疗前后的自然细胞毒性(自然杀伤细胞、NK细胞以及淋巴因子激活的杀伤细胞、LAK细胞活性)。治疗导致循环中CD56+淋巴细胞显著增加(治疗前:12.1±6.9%,平均值±标准差;治疗后:39.2±6.9%)。rIL-2治疗诱导了最大的NK细胞活性,但仅获得了LAK细胞细胞毒性的次优增强。这项研究表明,尽管持续输注rIL-2确实对自然细胞毒性有显著影响,但这是次优的,需要进一步研究来确定最有效的免疫增强治疗方案,从而有望改善rIL-2治疗的临床结果。