药物研发中的天然产物。2005年6月27 - 28日，英国伦敦

Natural Products in Drug Discovery and Development. 27-28 June 2005, London, UK.

作者信息

Harvey A

机构信息

Strathclyde Institute for Drug Research, University of Strathclyde, Glasgow, G4 ONR, UK.

出版信息

IDrugs. 2005 Sep;8(9):719-21.

PMID:16118691

Abstract

The meeting covered many aspects of the use of natural products in drug discovery and development. The historical and current contributions of natural products to the main classes of medicines, technical improvements to the supply of marine microbial products by fermentation and molecular biology and the value of natural chemical diversity for providing patentable, drug-like lead molecules were among the topics discussed. Several compounds in current clinical trials were described; these included several anticancer compounds and two compounds in development by Phytopharm plc, PYM-50028 (Cogane) and PYM-50018 (Myogane), for the treatment of neurodegenerative disease.

摘要

会议涵盖了天然产物在药物发现与开发中的诸多应用方面。天然产物对主要药物种类的历史及当前贡献、通过发酵和分子生物学技术改进海洋微生物产品的供应以及天然化学多样性在提供可获专利的类药物先导分子方面的价值等都是讨论的主题。会上介绍了几种正在进行临床试验的化合物；其中包括几种抗癌化合物以及Phytopharm plc公司正在研发的用于治疗神经退行性疾病的两种化合物，即PYM - 50028（Cogane）和PYM - 50018（Myogane）。