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[A synthesis of tritium-labeled olanzapine].

作者信息

Shevchenko V P, Nagaev I Iu, Kuznetsov Iu V, Polunin E V, Zozulia A A, Miasoedov N F

出版信息

Bioorg Khim. 2005 Jul-Aug;31(4):420-4. doi: 10.1007/s11171-005-0052-2.

Abstract

A synthesis of olanzapine, 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine was carried out, and the conditions for its tritium labeling were optimized, to get a tritium-labeled olanzapine preparation with molar radioactivity of 12 Ci/mmol.

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