钌催化2-烯基吡啶与芳基溴的芳基化反应：与宫泽-赫克反应不同的E、Z选择性
Ruthenium-catalyzed arylation of 2-alkenylpyridines with aryl bromides: alternative E,Z-selectivity to Mizoroki-Heck reaction.
作者信息
Oi Shuichi, Sakai Kaori, Inoue Yoshio
机构信息
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan.
出版信息
Org Lett. 2005 Sep 1;7(18):4009-11. doi: 10.1021/ol051654l.
PMID:16119954
Abstract
Regio- and stereoselective arylation of 2-alkenylpyridines with aryl bromides is catalyzed by specific Ru(II)-phosphine complexes affording beta-arylated (Z)-2-alkenylpyridines, in which the aryl moiety is introduced cis to the pyridyl group. This geometrical selectivity is in sharp contrast to the Mizoroki-Heck reaction. [reaction: see text]
摘要
特定的钌（II）-膦配合物催化2-烯基吡啶与芳基溴的区域和立体选择性芳基化反应，生成β-芳基化的（Z）-2-烯基吡啶，其中芳基部分与吡啶基呈顺式引入。这种几何选择性与Mizoroki-Heck反应形成鲜明对比。[反应：见正文]
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