DBH -1021 C/T基因多态性与酒精中毒无关，但可能与患者遭受生活事件的情况有关。
The DBH -1021 C/T polymorphism is not associated with alcoholism but possibly with patients' exposure to life events.
作者信息
Freire M T M V, Hutz M H, Bau C H D
机构信息
Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
J Neural Transm (Vienna). 2005 Sep;112(9):1269-74. doi: 10.1007/s00702-005-0339-8.
Two DBH polymorphisms were investigated in 114 Brazilian alcoholics of European descent and 233 controls. Personality and life events were also analyzed among alcoholics. No significant differences were observed in allele or genotype frequencies between alcoholics and controls. No association was detected between the polymorphisms and personality dimensions. Carriers of the -1021 T allele presented a higher number (F = 7.49; P = 0.007) of life events. This study provides a preliminary indication that the DBH -1021 C/T polymorphism influences the exposure to life events.
在114名欧洲裔巴西酗酒者和233名对照者中研究了两种DBH基因多态性。还对酗酒者的人格和生活事件进行了分析。酗酒者和对照者之间在等位基因或基因型频率上未观察到显著差异。未检测到多态性与人格维度之间存在关联。携带-1021 T等位基因者出现的生活事件数量更多（F = 7.49；P = 0.007）。本研究提供了初步迹象表明DBH -1021 C/T基因多态性会影响生活事件的暴露情况。
Zotero 插件