Zajaczkowska Małgorzata, Zinkiewicz Zofia, Bieniaś Beata, Piechuta Leszek, Szajner-Milart Irena, Majewski Marek
Department of Paediatric Nephrology, Skubiszewski Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2004;59(2):275-83.
The aim of the study was the retrospective analysis of the results of the drug sensitivity studies of bacterial species cultured from 681 urinary specimens collected from 79 children (12 boys and 67 girls) aged 0-18 years with recurrent urinary tract infection in a period from 1997 to 2001. Factors predisposing to recurrent urinary tract infections and the incidences of particular uropathogens were also analyzed. Escherichia coli (57.3%), Proteus spp. (15.6%) and Pseudomonas aeruginosa (9.1%) were the most frequent isolated pathogens. Reinfections and relapses of urinary tract infections were observed in 74.7% and 25.3% of the children, respectively. In some children etiologic variability of particular infection episodes were observed. In the majority of the children infection episodes were caused by one or two bacterial species and new infections differed from previous ones only in drug sensitivity. In 30 children vesicoureteral reflux was detected. Other anatomical abnormalities of urinary tract were revealed in 17 children. In 18 children, neurogenic bladder dysfunction was diagnosed. Urodynamics disclosed functional abnormalities in 48/55 children.
本研究旨在回顾性分析1997年至2001年期间从79名0至18岁复发性尿路感染儿童(12名男孩和67名女孩)采集的681份尿液标本中培养出的细菌种类的药敏试验结果。还分析了易患复发性尿路感染的因素以及特定尿路病原体的发生率。大肠埃希菌(57.3%)、变形杆菌属(15.6%)和铜绿假单胞菌(9.1%)是最常见的分离病原体。分别在74.7%和25.3%的儿童中观察到尿路感染的再感染和复发。在一些儿童中观察到特定感染发作的病因变异性。大多数儿童的感染发作由一两种细菌引起,新感染与先前感染的区别仅在于药敏性。在30名儿童中检测到膀胱输尿管反流。在17名儿童中发现了其他尿路解剖异常。在18名儿童中诊断出神经源性膀胱功能障碍。尿动力学检查显示55名儿童中有48名存在功能异常。