胶质纤维酸性蛋白在自闭症患者的额上回、顶叶和小脑皮质中升高。
Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects.
作者信息
Laurence J A, Fatemi S H
机构信息
Division of Neuroscience Research, University of Minnesota Medical School, Minneapolis, MN, USA.
出版信息
Cerebellum. 2005;4(3):206-10. doi: 10.1080/14734220500208846.
Autism is a debilitating neurodevelopmental disorder of early childhood with both genetic and environmental origins. Immune system dysregulation has been hypothesized to be involved in this disorder. We quantified levels of glial fibrillary acidic protein (GFAP) and ss-actin in three areas of the brain, namely, area 9, area 40 and cerebellum, in age matched autistic and control postmortem specimen using SDS-PAGE and western blotting techniques. Significant elevations in levels of GFAP were observed in all three brain areas in autism. This report confirms a recent report showing microglial and astroglial activation in autism. Increased GFAP levels in autistic brains signify gliosis, reactive injury, and perturbed neuronal migration processes.
自闭症是一种在儿童早期出现的、由遗传和环境因素共同导致的、使人衰弱的神经发育障碍。免疫系统失调被认为与这种疾病有关。我们使用SDS-聚丙烯酰胺凝胶电泳（SDS-PAGE）和蛋白质免疫印迹技术，对年龄匹配的自闭症患者和对照者的死后大脑标本中脑的三个区域（即9区、40区和小脑）的胶质纤维酸性蛋白（GFAP）和β-肌动蛋白水平进行了定量分析。在自闭症患者的所有三个脑区中均观察到GFAP水平显著升高。本报告证实了最近一份显示自闭症患者中存在小胶质细胞和星形胶质细胞激活的报告。自闭症大脑中GFAP水平的升高表明存在神经胶质增生、反应性损伤和神经元迁移过程紊乱。
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