Simmonds Peter, Bukh Jens, Combet Christophe, Deléage Gilbert, Enomoto Nobuyuki, Feinstone Stephen, Halfon Phillippe, Inchauspé Geneviève, Kuiken Carla, Maertens Geert, Mizokami Masashi, Murphy Donald G, Okamoto Hiroaki, Pawlotsky Jean-Michel, Penin François, Sablon Erwin, Shin-I Tadasu, Stuyver Lieven J, Thiel Heinz-Jürgen, Viazov Sergei, Weiner Amy J, Widell Anders
Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, United Kingdom.
Hepatology. 2005 Oct;42(4):962-73. doi: 10.1002/hep.20819.
International standardization and coordination of the nomenclature of variants of hepatitis C virus (HCV) is increasingly needed as more is discovered about the scale of HCV-related liver disease and important biological and antigenic differences that exist between variants. A group of scientists expert in the field of HCV genetic variability, and those involved in development of HCV sequence databases, the Hepatitis Virus Database (Japan), euHCVdb (France), and Los Alamos (United States), met to re-examine the status of HCV genotype nomenclature, resolve conflicting genotype or subtype names among described variants of HCV, and draw up revised criteria for the assignment of new genotypes as they are discovered in the future. A comprehensive listing of all currently classified variants of HCV incorporates a number of agreed genotype and subtype name re-assignments to create consistency in nomenclature. The paper also contains consensus proposals for the classification of new variants into genotypes and subtypes, which recognizes and incorporates new knowledge of HCV genetic diversity and epidemiology. A proposal was made that HCV variants be classified into 6 genotypes (representing the 6 genetic groups defined by phylogenetic analysis). Subtype name assignment will be either confirmed or provisional, depending on the availability of complete or partial nucleotide sequence data, or remain unassigned where fewer than 3 examples of a new subtype have been described. In conclusion, these proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future.
随着人们对丙型肝炎病毒（HCV）相关肝病的规模以及不同病毒变体之间存在的重要生物学和抗原差异有了更多了解，对HCV病毒变体命名的国际标准化和协调的需求日益增加。一群在HCV基因变异性领域的科学家以及参与HCV序列数据库（日本的肝炎病毒数据库、法国的euHCVdb和美国的洛斯阿拉莫斯数据库）开发的人员齐聚一堂，重新审视HCV基因型命名的现状，解决已描述的HCV变体中相互冲突的基因型或亚型名称，并制定未来发现新基因型时的修订分配标准。一份全面列出所有当前已分类的HCV变体的清单纳入了一些商定的基因型和亚型名称重新分配，以实现命名的一致性。该论文还包含了将新变体分类为基因型和亚型的共识提议，其中认可并纳入了关于HCV遗传多样性和流行病学的新知识。有人提议将HCV变体分为6个基因型（代表通过系统发育分析定义的6个基因群）。亚型名称的分配将根据完整或部分核苷酸序列数据的可用性确定为确认或暂定，或者在新亚型的描述少于3个实例的情况下保持未分配状态。总之，这些提议提供了一个框架，HCV数据库可借此存储和提供HCV数据访问，这将在未来国际上协调新基因型和亚型的分配。
