Li Jianchang, Rush Thomas S, Li Wei, DeVincentis Dianne, Du Xuemei, Hu Yonghan, Thomason Jennifer R, Xiang Jason S, Skotnicki Jerauld S, Tam Steve, Cunningham Kristina M, Chockalingam Priya S, Morris Elisabeth A, Levin Jeremy I
Department of Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.
Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6. doi: 10.1016/j.bmcl.2005.08.001.
The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
本文描述了一系列新型联苯磺酰胺羧酸的基于结构的设计与合成，这些化合物是强效的MMP - 13抑制剂，对MMP - 1、MMP - 2、MMP - 3、MMP - 7、MMP - 8、MMP - 9、MMP - 14、聚集蛋白聚糖酶1和肿瘤坏死因子α转换酶具有选择性。
Zotero 插件