Allosteric modulation of the nicotinic acetylcholine receptor by physostigmine.
作者信息
Svobodová Lucie, Krusek Jan, Hendrych Tomás, Vyskocil Frantisek
机构信息
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
出版信息
Ann N Y Acad Sci. 2005 Jun;1048:355-8. doi: 10.1196/annals.1342.037.
PMID:16154951
Abstract
The action of physostigmine on mouse muscle nicotinic acetylcholine receptor expressed in the COS-7 cell line was studied by the patch-clamp technique. Physostigmine accelerated, by allosteric modulation, the rate of desensitization of whole cell currents induced by acetylcholine and decreased the maximal amplitude in concentration-dependent manner.
摘要
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