布基纳法索瓦加杜古新生儿镰状细胞疾病筛查：一项试点研究。
Neonatal screening for sickle cell disorders in Ouagadougou, Burkina Faso: a pilot study.
作者信息
Kafando Eléonore, Sawadogo Mamadou, Cotton Frédéric, Vertongen Fanchon, Gulbis Béatrice
机构信息
Laboratory of Haematology and Clinical Chemistry, Faculté des Sciences de la Santé, Université de Ouagadougou, Ouagadougou, Burkina Faso.
出版信息
J Med Screen. 2005;12(3):112-4. doi: 10.1258/0969141054855300.
OBJECTIVES
To determine the incidence of sickle cell disorders (SCDs) and the feasibility of a neonatal screening programme in Ouagadougou.
METHODS
During 2000, 2003 and 2004, 2341 cord blood samples obtained in five maternity hospitals in Ouagadougou were screened for SCDs using an isoelectric focusing technique. The feasibility of a neonatal screening programme was evaluated.
RESULTS
The incidence of SCD was 1:57; 14 neonates were homozygous for haemoglobin (Hb)S and 27 were compound heterozygotes for HbSC. Thirty-two neonates were homozygous for HbC. The incidence of the HbC trait was 1:6; incidence of the HbS trait was 1:14. A centralized laboratory for neonatal screening of SCDs was established.
CONCLUSIONS
SCDs should be considered a major public health problem in Ouagadougou. A neonatal screening programme should be implemented, but to be effective it requires strategies adapted to the local situation.
目的
确定瓦加杜古镰状细胞疾病（SCDs）的发病率以及新生儿筛查项目的可行性。
方法
在2000年、2003年和2004年期间，使用等电聚焦技术对在瓦加杜古五家妇产医院采集的2341份脐带血样本进行SCDs筛查。对新生儿筛查项目的可行性进行了评估。
结果
SCD的发病率为1:57；14名新生儿为血红蛋白（Hb）S纯合子，27名是HbSC复合杂合子。32名新生儿为HbC纯合子。HbC性状的发病率为1:6；HbS性状的发病率为1:14。建立了一个用于SCDs新生儿筛查的中央实验室。
结论
在瓦加杜古，SCDs应被视为一个主要的公共卫生问题。应实施新生儿筛查项目，但要使其有效，需要采取适应当地情况的策略。
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