临床前亨廷顿病的局部皮质变薄及其与认知的关系。
Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.
作者信息
Rosas H D, Hevelone N D, Zaleta A K, Greve D N, Salat D H, Fischl B
机构信息
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Neurology. 2005 Sep 13;65(5):745-7. doi: 10.1212/01.wnl.0000174432.87383.87.
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
作者对携带亨廷顿舞蹈病（HD）突变的无症状个体进行了研究，以确定是否存在皮质变薄的情况。他们发现这种变薄具有区域选择性，与纹状体体积减少半独立相关，且与认知表现相关。在HD临床前阶段就会出现早期广泛的皮质受累。
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