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[血管内皮生长因子、血管内皮生长因子-C及血管内皮生长因子-D在甲状腺乳头状癌中的表达及意义]

[Expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma].

作者信息

Jiang Han-Guo, Gao Mei, Tang Wei-Ping, Li Fei-Hong, Cai Qiong-Zhen

机构信息

Department of Pathology, Guangdong Medical College, Zhanjiang, Guangdong, P.R. China.

出版信息

Ai Zheng. 2005 Sep;24(9):1136-9.

PMID:16159441

Abstract

BACKGROUND & OBJECTIVE: Vascular endothelial growth factor-C and -D (VEGF-C, VEGF-D) are related to lymphangiogenesis. Papillary thyroid carcinoma is characterized by regional lymph node metastasis. This study was designed to determine the expression and significance of VEGF, VEGF-C, and VEGF-D in papillary thyroid carcinoma.

METHODS

The expression of VEGF, VEGF-C, and VEGF-D in 115 specimens of papillary thyroid carcinoma and 20 specimens of nodular goiter were detected by SP immunohistochemistry.

RESULTS

Positive rates of VEGF, VEGF-C, and VEGF-D were significantly higher in papillary thyroid carcinoma than in nodular goiter (79.1% vs. 30.0%, 87.0% vs. 15.0%, and 72.2% vs. 20.0%, P<0.01). The expression of VEGF was closely related to the size of papillary thyroid carcinoma. Positive rates of VEGF were 84.7% in lymph node positive group, and 73.2% in lymph node negative group. Positive rates of VEGF-C and VEGF-D were significantly higher in lymph node positive group than in lymph node negative group (93.2% vs. 80.4%, P<0.05; 83.1% vs. 60.7%, P<0.01).

CONCLUSION

VEGF is closely related to tumor growth of papillary thyroid carcinoma; while VEGF-C and VEGF-D are closely related to lymph node metastasis of papillary thyroid carcinoma, and may be predictors of lymph node metastasis.

摘要

背景与目的

血管内皮生长因子C和D（VEGF-C、VEGF-D）与淋巴管生成有关。甲状腺乳头状癌以区域淋巴结转移为特征。本研究旨在确定VEGF、VEGF-C和VEGF-D在甲状腺乳头状癌中的表达及意义。

方法

采用SP免疫组织化学法检测115例甲状腺乳头状癌标本和20例结节性甲状腺肿标本中VEGF、VEGF-C和VEGF-D的表达。

结果

甲状腺乳头状癌中VEGF、VEGF-C和VEGF-D的阳性率显著高于结节性甲状腺肿（分别为79.1%对30.0%、87.0%对15.0%、72.2%对20.0%，P<0.01）。VEGF的表达与甲状腺乳头状癌的大小密切相关。淋巴结阳性组VEGF阳性率为84.7%，淋巴结阴性组为73.2%。淋巴结阳性组VEGF-C和VEGF-D的阳性率显著高于淋巴结阴性组（分别为93.2%对80.4%，P<0.05；83.1%对60.7%，P<0.01）。