Oltrona Luigi, Mafrici Antonio, Marzegalli Maurizio, Fiorentini Cesare, Pirola Roberto, Vincenti Antonio
Dipartimento di Cardiologia e Cardiochirurgia A. De Gasperis, Ospedale Niguarda Ca' Granda, Milano.
Ital Heart J Suppl. 2005 Aug;6(8):489-97.
Recent international and national surveys on the management of ST-elevation myocardial infarction have described a number of crucial issues regarding the prehospital phase, the criteria to address patients to primary angioplasty, the organization of interhospital transfers. GestIMA is a perspective survey organized by the Lombardy Sections of the Italian Cardiology Societies (ANMCO and SIC) aimed to investigate the management of the acute phase of myocardial infarction in the Lombardy Region.
Between October 15 and November 14, 2003, consecutive patients hospitalized for ST-elevation myocardial infarction in the coronary care units of 60 hospitals in Lombardy were enrolled into the study.
Among 612 patients (median age 67 years, interquartile range 56-76 years, 68% males, 43% with acute anterior myocardial infarction), 43% reached the hospital using the 118 emergency medical service, in 20% an ECG was recorded before arrival (reported in 47%), 1.5% were treated with thrombolysis and 1.0% with glycoprotein IIb/IIIa inhibitors before hospital admission. Sixty-eight percent of patients underwent a reperfusion treatment: 43% with primary angioplasty (6% facilitated), 25% with thrombolysis (18% of them had rescue angioplasty). Primary angioplasty was mainly performed in younger patients and in those directly admitted to centers equipped with interventional facilities. During the acute phase of myocardial infarction, 10% of patients arrived to the coronary care units from 39 peripheral hospitals without coronary care unit; 21% of patients had a secondary transport between hospitals with coronary care unit (47% for primary angioplasty).
In the Lombardy Region, where a high rate of patients with ST-elevation myocardial infarction was treated with primary angioplasty in 2003, the 118 emergency medical service and the transmission of ECG by telephone are still underutilized. Moreover, the prehospital pharmacological treatment, the prehospital triage of patients to address to primary angioplasty and the organization of secondary transfer need to be improved.
近期关于ST段抬高型心肌梗死管理的国际和国内调查描述了一些关于院前阶段、将患者转至直接经皮冠状动脉介入治疗的标准以及医院间转运组织等关键问题。GestIMA是由意大利心脏病学会伦巴第分会(ANMCO和SIC)组织的一项前瞻性调查,旨在研究伦巴第地区心肌梗死急性期的管理情况。
2003年10月15日至11月14日期间,伦巴第60家医院冠心病监护病房中因ST段抬高型心肌梗死住院的连续患者被纳入研究。
在612例患者中(中位年龄67岁,四分位间距56 - 76岁,68%为男性,43%为急性前壁心肌梗死),43%通过118急救医疗服务到达医院,20%在到达前记录了心电图(47%报告有心电图),1.5%在入院前接受了溶栓治疗,1.0%在入院前接受了糖蛋白IIb/IIIa抑制剂治疗。68%的患者接受了再灌注治疗:43%接受直接经皮冠状动脉介入治疗(6%为辅助性),25%接受溶栓治疗(其中18%进行了补救性经皮冠状动脉介入治疗)。直接经皮冠状动脉介入治疗主要在年轻患者以及直接入住具备介入设施中心的患者中进行。在心肌梗死急性期,10%的患者从39家没有冠心病监护病房的外围医院转入冠心病监护病房;21%的患者在有冠心病监护病房的医院之间进行了二次转运(47%是为了进行直接经皮冠状动脉介入治疗)。
在伦巴第地区,2003年有很高比例的ST段抬高型心肌梗死患者接受了直接经皮冠状动脉介入治疗,但118急救医疗服务和通过电话传输心电图的使用率仍然较低。此外,院前药物治疗、将患者院前分诊至直接经皮冠状动脉介入治疗以及二次转运的组织都需要改进。