Singer Jennifer S, Ettenger Robert B, Gore John L, Gritsch H Albin, Rajfer Jacob, Rosenthal J Thomas, Schulam Peter
Department of Urology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, USA.
Am J Transplant. 2005 Oct;5(10):2514-20. doi: 10.1111/j.1600-6143.2005.01061.x.
Despite reports demonstrating the safety of laparoscopic donor nephrectomy (LDN) for pediatric recipients of renal transplants, recent evidence has challenged using LDN for recipients 5 years of age or younger. We retrospectively reviewed the records of all pediatric recipients of living donor renal transplants from September 2000 through August 2004. We compared those who received allografts recovered by LDN (n = 34) with those recovered by open donor nephrectomy (ODN, n = 26). Outcomes of interest included operative complications, postoperative renal function, the incidence of delayed graft function or episodes of acute rejection and long-term graft function. Donor and recipient demographic data were similar for the LDN and ODN groups. Serum creatinine and calculated creatinine clearance were not significantly different between groups both in the early postoperative period and at long-term follow-up (p > 0.142). Rates of delayed graft function and acute rejection did not differ between groups. Among recipients aged 5 years old or younger stratified by donor technique (9 LDN, 5 ODN recipients), no difference was noted in graft outcomes both early and long-term (p > 0.079). At our center, pediatric LDN recipients have graft outcomes comparable to those of ODN recipients. At experienced centers, we recommend continued use of LDN for pediatric recipients of all ages.
尽管有报告表明腹腔镜供体肾切除术(LDN)对小儿肾移植受者是安全的,但最近的证据对在5岁及以下受者中使用LDN提出了质疑。我们回顾性分析了2000年9月至2004年8月间所有活体供肾小儿移植受者的记录。我们将接受LDN获取的同种异体肾移植的受者(n = 34)与接受开放供体肾切除术(ODN,n = 26)获取的受者进行了比较。感兴趣的结局包括手术并发症、术后肾功能、移植肾功能延迟或急性排斥反应的发生率以及长期移植肾功能。LDN组和ODN组的供体和受者人口统计学数据相似。术后早期和长期随访时,两组间血清肌酐和计算的肌酐清除率均无显著差异(p > 0.142)。两组间移植肾功能延迟和急性排斥反应的发生率无差异。在按供体技术分层的5岁及以下受者中(9例LDN受者,5例ODN受者),早期和长期的移植结局均无差异(p > 0.079)。在我们中心,小儿LDN受者的移植结局与ODN受者相当。在经验丰富的中心,我们建议继续对所有年龄段的小儿受者使用LDN。