纯合子镰状细胞病中的抗磷脂抗体。
Antiphospholipid antibodies in homozygous sickle cell disease.
作者信息
De Ceulaer K, Khamashta M A, Harris E N, Serjeant G R, Hughes G R
机构信息
Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.
出版信息
Ann Rheum Dis. 1992 May;51(5):671-2. doi: 10.1136/ard.51.5.671.
Serum samples from 108 unselected Jamaican patients with homozygous sickle cell disease and 116 control subjects with normal haemoglobin were screened for the presence of antiphospholipid antibodies. Slightly increased levels of IgG antiphospholipid antibodies were found in nine patients with sickle cell disease and in none of the control subjects. Serial control samples confirmed the increased levels of antiphospholipid antibodies. A comparison of the haematological and clinical features of patients with positive and negative antiphospholipid sickle cell disease did not highlight any differences between the groups.
对108名未经挑选的患有纯合子镰状细胞病的牙买加患者和116名血红蛋白正常的对照者的血清样本进行了抗磷脂抗体检测。在9名镰状细胞病患者中发现IgG抗磷脂抗体水平略有升高，而对照者中未发现。连续的对照样本证实了抗磷脂抗体水平的升高。对抗磷脂抗体阳性和阴性的镰状细胞病患者的血液学和临床特征进行比较，未发现两组之间有任何差异。
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