通过钯催化串联烷基化/直接芳基化反应合成稠合吲哚的途径。
A route to annulated indoles via a palladium-catalyzed tandem alkylation/direct arylation reaction.
作者信息
Bressy Cyril, Alberico Dino, Lautens Mark
机构信息
Davenport Laboratories, Chemistry Department, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
出版信息
J Am Chem Soc. 2005 Sep 28;127(38):13148-9. doi: 10.1021/ja054472v.
PMID:16173734
Abstract
A norbornene-mediated palladium-catalyzed tandem alkylation/C-H functionalization sequence is described, in which an alkyl-aryl bond and a heteroaryl-aryl bond are formed in one pot. A variety of highly substituted six- and seven-membered ring annulated indoles were synthesized in good yields from bromoalkyl indoles and aryl iodides.
摘要
描述了一种降冰片烯介导的钯催化串联烷基化/C-H官能化序列，其中在一锅反应中形成了烷基-芳基键和杂芳基-芳基键。由溴烷基吲哚和芳基碘化物以良好的产率合成了多种高度取代的六元环和七元环稠合吲哚。
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