阳离子脂磷酰胺酯和脂磷胍对体内DNA递送非常有效。
Cationic lipophosphoramidates and lipophosphoguanidines are very efficient for in vivo DNA delivery.
作者信息
Picquet Erwann, Le Ny Karine, Delépine Pascal, Montier Tristan, Yaouanc Jean-Jacques, Cartier Dominique, des Abbayes Hervé, Férec Claude, Clément Jean-Claude
机构信息
UMR CNRS 6521, UFR Sciences et Techniques, Université de Bretagne Occidentale, 6, Av. Le Gorgeu, C.S. 93837, F-29238 Brest Cedex 3, France.
出版信息
Bioconjug Chem. 2005 Sep-Oct;16(5):1051-3. doi: 10.1021/bc050097k.
Two new families of cationic lipids were designed and synthesized for gene delivery, namely "lipophosphoramidates" and "lipophosphoguanidines", whose efficiency was noteworthy. The most efficient have an arsonium cation as the polar head, and the unsaturated lipidic tails (e.g. oleyl) gave the better in vivo results (mice lungs).
设计合成了两个用于基因递送的新型阳离子脂质家族，即“脂磷酸酰胺”和“脂磷酸胍”，其效率值得关注。最有效的是以砷鎓阳离子作为极性头部，不饱和脂质尾部（如油酰基）在体内（小鼠肺部）产生了更好的结果。
Zotero 插件