[神经精神性系统性红斑狼疮的特征性表现]
[Characteristic manifestations of neuropsychiatric systemic lupus erythematosus].
作者信息
Liu Zhi, Chen Lin, Cui Li-Ying
机构信息
Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
出版信息
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Aug;27(4):509-12.
OBJECTIVE
To investigate the characteristic manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE) in clinical practice.
METHODS
A total of 198 NPSLE cases from 1998 to 2003 in Peking Union Medical College Hospital, were included. Their clinical manifestations and the results of accessory examination such as serology, lumbar puncture, head magnetic resonance imaging, and electroencephalogram were analyzed.
RESULTS
The most frequent manifestations of the NPSLE included: headache, psychiatric disorder, seizure, stroke, and acute confusional state. Fifty-two patients took head magnic resonance imaging, and 34 of them showed abnormal, including stroke attack. Among 48 patients who only had a complaint of headache, the increase of intracranial pressure and cerebral spinal fluid protein was significantly higher than other NPSLE syndromes (P < 0.05).
CONCLUSION
Diagnosis of NPSLE was mainly based on its clinical manifestations. Head magnetic resonance imaging and cerebral spinal fluid examination may be helpful. More specific accessory examinations require further development.
目的
探讨神经精神性系统性红斑狼疮（NPSLE）在临床实践中的特征性表现。
方法
纳入1998年至2003年北京协和医院的198例NPSLE患者。分析其临床表现以及血清学、腰椎穿刺、头部磁共振成像和脑电图等辅助检查结果。
结果
NPSLE最常见的表现包括：头痛、精神障碍、癫痫发作、中风和急性意识模糊状态。52例患者进行了头部磁共振成像检查，其中34例显示异常，包括中风发作。在仅主诉头痛的48例患者中，颅内压和脑脊液蛋白升高明显高于其他NPSLE综合征（P<0.05）。
结论
NPSLE的诊断主要基于临床表现。头部磁共振成像和脑脊液检查可能有帮助。更具特异性的辅助检查有待进一步发展。
Zotero 插件