Siamopoulos K C, Elisaf M, Drosos A A, Mavridis A A, Moutsopoulos H M
Department of Internal Medicine, Medical School, University of Ioannina, Greece.
Clin Rheumatol. 1992 Jun;11(2):226-30. doi: 10.1007/BF02207962.
Renal tubular acidosis (RTA) is a frequent extraglandular manifestation of Sjögren's syndrome; however, no distinction on the incidence of this renal tubular defect between primary and secondary Sjögren's syndrome has been reported. This study was undertaken in order to define the frequency of RTA and the possible pathogenetic mechanisms in a group of 21 randomly selected primary Sjögren's syndrome patients. RTA was found in 7 (33%) patients. The incomplete type of the disorder was the most frequent. It seems that the etiology of RTA is multifactorial. Renal excretion of monoclonal proteins and the immunologically-induced interstitial inflammation are the main possible factors of this renal tubular defect.
肾小管酸中毒（RTA）是干燥综合征常见的腺体外表现；然而，原发性和继发性干燥综合征之间这种肾小管缺陷的发生率尚无差异报道。本研究旨在确定21例随机选取的原发性干燥综合征患者中RTA的发生率及可能的发病机制。7例（33%）患者发现有RTA。该疾病的不完全型最为常见。RTA的病因似乎是多因素的。单克隆蛋白的肾排泄和免疫诱导的间质性炎症是这种肾小管缺陷的主要可能因素。
