临床试验的途径。
Gateways to clinical trials.
作者信息
Bayes M, Rabasseda X, Prous J R
机构信息
Prous Science, Barcelona, Spain.
出版信息
Methods Find Exp Clin Pharmacol. 2005 Jul-Aug;27(6):411-61.
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug discovery and development portal, http://integrity.prous.com. This issue focuses on the following selection of drugs: (-)-Epigallocatechin gallate; ACP-103, Ad.Egr.TNF.11 D, adalimumab, AF-IL 12, AIDSVAX gp120 B/B, alefacept, alemtuzumab, a-Galactosylceramide, ALVAC vCP 1452, alvimopan hydrate, alvocidib hydrochloride, aminolevulinic acid hydrochloride, aminolevulinic acid methyl ester, anakinra, anidulafungin, antarelix, aprepitant, aripiprazole, arsenic sulfide, asoprisnil, atazanavir sulfate, atomoxetine hydrochloride; Bevacizumab, bimatoprost, BMS-184476, bortezomib, bosentan, botulinum toxin type B, BrachySil, brivudine; Caffeine, calcipotriol/betamethasone dipropionate, cannabidiol, capsaicin for injection, caspofungin acetate, CC-4047, cetuximab, CGP-36742, clofazimine, CpG-7909, Cypher; Darbepoetin alfa, dextromethorphan/quinidine sulfate, dimethylfumarate, dronabinol/cannabidiol, drotrecogin alfa (activated), duloxetine hydrochloride, dutasteride; Ecogramostim, efalizumab, eletriptan, emtricitabine, enfuvirtide, eplerenone, esomeprazole magnesium, estradiol acetate, eszopiclone, etoricoxib, exenatide, ezetimibe, ezetimibe/simvastatin; Fampridine, fondaparinux sodium, fosamprenavir calcium; Gefitinib, GPI-0100; hA 20, HTU-PA, human insulin, HuOKT 3 gamma 1(Ala 234-Ala 235), hyaluronic acid; Icatibant, imatinib mesylate, Indiplon, INKP-100, INKP-102, iodine (I131) tositumomab, istradefylline, IV gamma-globulin, ivabradine hydrochloride, ixabepilone; Lacosamide, landiolol, lanthanum carbonate, lasofoxifene tartrate, LB-80380, lenalidomide, lidocaine/tetracaine, linezolid, liposomal doxorubicin, liposomal vincristine sulfate, lopinavir, lopinavir/ritonavir, lumiracoxib, lurtotecan; Maribavir, morphine glucuronide, MVA-5 T 4; NBI-56418, NCX-4016, nesiritide, nicotine conjugate vaccine, NSC-330507; Oglufanide, omalizumab, oxipurinol; Palifermin, palonosetron hydrochloride, parecoxib sodium, PEG-filgrastim, peginterferon alfa-2a, peginterferon alfa-2b, peginterferon alfa-2b/ribavirin, PEGylated interferon alfacon-1, perospirone hydrochloride, pimecrolimus, pixantrone maleate, plerixafor hydrochloride, PowderJect lidocaine, pradefovir mesylate, prasterone, pregabalin, Prostvac VF, PT-141, PTC-124, pyridoxamine; QS-21, quercetin; R-126638, R-411, ralfinamide, rasagiline mesilate, rF-PSA, RG-2077, rhThrombin, rimonabant hydrochloride, rofecoxib, rosuvastatin calcium, rotigotine hydrochloride, rV-PSA; S-18886, S-303, seocalcitol, SGN-40, sitaxsentan sodium, SPP-301, St. John's Wort extract; Tadalafil, taxus, telithromycin, tenatoprazole, tenofovir disoproxil fumarate, testosterone MDTS, testosterone transdermal patch, tgAAC-09, TH-9507, thioacetazone, tipifarnib, TQ-1011, trabectedin, travoprost, trimethoprim; Valdecoxib, valganciclovir hydrochloride, valopicitabine, voriconazole; Xcellerated T cells.
临床试验指南是当前文献和会议中最新临床试验的指南。以下表格中的数据取自药物研发门户网站Prous Science Integrity的临床试验知识领域，网址为http://integrity.prous.com。本期重点关注以下几种药物：（-）-表没食子儿茶素没食子酸酯；ACP - 103、Ad.Egr.TNF.11 D、阿达木单抗、AF - IL 12、AIDSVAX gp120 B/B、阿法赛特、阿仑单抗、α - 半乳糖神经酰胺、ALVAC vCP 1452、水合阿洛司琼、盐酸阿伐替尼、盐酸氨基乙酰丙酸、氨基乙酰丙酸甲酯、阿那白滞素、阿尼芬净、安他瑞克、阿瑞匹坦、阿立哌唑、硫化砷、阿索普瑞诺、硫酸阿扎那韦、盐酸托莫西汀；贝伐单抗、比马前列素、BMS - 184476、硼替佐米、波生坦、B型肉毒毒素、BrachySil、溴夫定；咖啡因、卡泊三醇/倍他米松二丙酸酯、大麻二酚、注射用辣椒素、醋酸卡泊芬净、CC - 4047、西妥昔单抗、CGP - 36742、氯法齐明、CpG - 7909、西罗莫司洗脱支架； darbepoetin alfa、右美沙芬/硫酸奎尼丁、富马酸二甲酯、屈大麻酚/大麻二酚、活化蛋白C、盐酸度洛西汀、度他雄胺；Ecogramostim、依法利珠单抗、依来曲普坦、恩曲他滨、恩夫韦肽、依普利酮、埃索美拉唑镁、醋酸雌二醇、艾司佐匹克隆、依托考昔、艾塞那肽、依折麦布、依折麦布/辛伐他汀；法吡拉西坦、磺达肝癸钠、福沙普那韦钙；吉非替尼、GPI - 0100；hA 20、HTU - PA、人胰岛素、HuOKT 3 gamma 1(Ala 234 - Ala 235)、透明质酸；伊卡替班、甲磺酸伊马替尼、Indiplon、INKP - 100、INKP - 102、碘（I131）托西莫单抗、异他林、静脉注射丙种球蛋白、盐酸伊伐布雷定、伊沙匹隆；拉科酰胺、兰地洛尔、碳酸镧、酒石酸拉索昔芬、LB - 80380、来那度胺、利多卡因/丁卡因、利奈唑胺、脂质体阿霉素、脂质体硫酸长春新碱、洛匹那韦、洛匹那韦/利托那韦、鲁米昔布、鲁替康；马立巴韦、吗啡葡萄糖醛酸苷、MVA - 5 T 4；NBI - 56418、NCX - 4016、奈西立肽、尼古丁结合疫苗、NSC - 330507；奥卢法尼德、奥马珠单抗、奥昔嘌醇；帕利夫明、盐酸帕洛诺司琼、帕罗西汀钠、聚乙二醇化重组人粒细胞集落刺激因子、聚乙二醇化干扰素α - 2a、聚乙二醇化干扰素α - 2b、聚乙二醇化干扰素α - 2b/利巴韦林、聚乙二醇化干扰素α - 1、盐酸哌罗匹隆、吡美莫司、马来酸匹杉琼、盐酸普乐沙福、注射用利多卡因、甲磺酸普拉德福韦、普拉睾酮、普瑞巴林、Prostvac VF、PT - 141、PTC - 124、吡哆胺；QS - 21、槲皮素；R - 126638、R - 411、瑞芬酰胺、甲磺酸雷沙吉兰、重组人前列腺特异性抗原、RG - 2077、人凝血酶、盐酸利莫那班、罗非昔布、瑞舒伐他汀钙、盐酸罗替戈汀、重组人前列腺特异性抗原；S - 18886、S - 303、司骨化醇、SGN - 40、西他生坦钠、SPP - 301、圣约翰草提取物；他达拉非、红豆杉、泰利霉素、替那拉唑、替诺福韦酯富马酸盐、睾酮MDTS、睾酮透皮贴剂、tgAAC - 09、TH - 9507、硫代乙酰胺、替匹法尼、TQ - 1011、曲贝替定、曲伏前列素、甲氧苄啶；伐地昔布、盐酸缬更昔洛韦、伐洛西他滨、伏立康唑；加速T细胞。
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